2)

2). was inhibited by pifithrin-, an inhibitor of p53 transcriptional activity. Furthermore, 1,3-DNP brought on an unfolded protein response (UPR), as measured by an increased expression of CHOP, AT... Read More

Unfortunately, detailed structural biology studies on STAT3 as well as target-based drug discovery attempts have been hampered by difficulties in the expression and purification of the full-length STAT3 and a lack of ligand-bound crystal structures

Unfortunately, detailed structural biology studies on STAT3 as well as target-based drug discovery attempts have been hampered by difficulties in the expression and purification of the full-length ... Read More